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SCIENTIFIC PROGRAM |
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Morning |
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10:00 AM |
Registration of the participants |
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05:00 PM |
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Afternoon |
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02:00 PM |
Concurrent Meetings of the E.C.A. Permanent Working Groups |
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Coordinator K. Madan (The Netherlands) |
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Cancer Cytogenetics, Solid Tumor Studies within Cost Action B19 (02:00 PM - 05:00 PM) |
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"Molecular Cytogenetics of Solid Tumor" meeting, 2-5 PM - Europauditorium |
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| "What causes aneuploidy and chromosome rearrangements?" | ||
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Chaired by O. Haas (Austria) and L. Larizza (Italy) |
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| Introduction | ||
| P. Duesberg (USA) (invited expert) | ||
| Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy | ||
| A. Krämer (Denmark) | ||
| Centrosome aberrations and cancer development | ||
| C. Griffin (UK) | ||
| Aneuploidy, centrosome activity and chromosome instability in cells deficient in homologous recombination repair | ||
| M. Schwab (Germany) | ||
| Oncogene amplification and fragile sites | ||
| M. Höglund (Sweden) | ||
| Coping with complexity. multivariate analysis of tumor karyotypes | ||
| R. Siebert (Germany) | ||
| Cytogenetic evolution in malignant tumors:from patterns to hypotheses | ||
| Discussion | ||
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European Association of Cytogenetic Technologists EACT, 2-4 PM – Room I |
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Chaired by E. Ormerod, I Sissel (Norway), B.Strömbeck (Sweden), G. Sander (Austria) |
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Clinical and Molecular Approach of Cytogenetic Syndromes - Room II |
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Chaired by A. Schinzel (Switzerland) and C. v. Ravenswaaij (The Netherlands) |
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Cytogenetic Toxicology and Mutagenesis – Room III |
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Chaired by J.B. Bureau (France) and J. Garcia-Sagredo (Spain) |
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Chromosome Nomenclature, Databases and Networks – Sala Bianca |
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Chaired by J.-L. Huret (France) and N. Tommerup (Denmark) |
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| A. Schinzel | ||
| A cytogenetic database | ||
| N. Tommerup | ||
| Mendelian Cytogenetic Network Database | ||
| M. Rocchi | ||
| Resources for Molecular Cytogenetics | ||
| F. Mertens | ||
| Database of Chromosome Aberrations in Cancer | ||
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03:00 PM |
Chromosome Fragility – Room II |
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Chaired by J.P. Fryns (Belgium) |
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Molecular Cytogenetics – Sala Bianca |
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Chaired by M. Rocchi (Italy) |
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| M. Rocchi | ||
| Resources for Molecular Cytogenetics | ||
| J.-L. Huret | ||
| The Atlas of Genetics and Cytogenetics in Oncology and Haematology | ||
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04:00 PM |
Animal, Plant, and Comparative Cytogenetics – Room I |
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Chaired by P. Popescu (France) |
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| Open discussions on following points: | ||
| 1. Preparation of a celebration meeting on "40 years of 1/29 translocation in cattle" | ||
| 2. New approaches for cytogenetics in transgenic and animal clones | ||
| 3. Karyotype standardisation of different animal species | ||
| 4. Miscellaneous | ||
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Cytogenetics and Society – Room II |
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Chaired by F. Dagna Bricarelli (Italy) and U. Kristoffersson (Sweden) |
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| T. Nilsson, S. Cavani | ||
| Report on QA-status in Europe | ||
| A. Horvath, I. R. van der Werff | ||
| An educational programme for cytogenetic technologist | ||
| V. Davison | ||
| Accreditation of cytogenetics laboratories – similarities and differences: the view from an inspector and supervisor | ||
| F. Dagna Bricarelli, U. Kristoffersson | ||
| Closing discussion. The future of the PWG | ||
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Research in the Service Environment, |
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together with Prenatal Diagnosis – Room III |
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Chaired by M. Hulten (U.K.), E. Ormerod (Norway) and J. Wolstenholme (U.K.) |
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Chromosome Structure and Function. Interphase nucleus studies- Sala Bianca |
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Chaired by T. Cremer (Germany) |
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05:30 PM |
Opening ceremony – Europauditorium |
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Honorary lecture |
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E. Engel |
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Some lessons from UPD in the framework of contemporary cytogenetics and molecular biology |
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Chaired by L. Larizza (Italy), A. Schinzel (Switzerland) |
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07:00 PM |
Welcome Reception - Foyer Italia |
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Morning |
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09:00 AM |
Plenary session – Europauditorium |
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Duplicons, Centromeres, telomeres and chromosome rearrangements |
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Chaired by G. Neri (Italy), A. Schinzel (Switzerland) |
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E. Eichler |
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| Understanding the origin and impact of segmental duplications: a comparison of human and mouse genomes | ||
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O. Zuffardi |
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| Molecular bases for chromosome rearrangements | ||
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M. Rocchi |
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| Centromere plasticity in evolution | ||
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selected abstracts: |
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A. Barbouti |
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| The breakpoint region of the most common isochromosome, i(17q), in human neoplasia is characterized by a complex genomic architecture with large palindromic low-copy repeats | ||
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M. Ventura |
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| Neocentromeres in 15q24-26 map to duplicons which flanked an ancestral centromere in 15q25 | ||
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M. Zollino |
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| Structural chromosome anomalies in MR/MCA syndromes: conventional cytogenetics and telomere analysis. | ||
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11:00 AM |
Coffee-break and Trade Exhibition |
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11:30 AM |
Clinical cytogenetics – Europauditorium |
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Chaired by K. Madan (The Netherlands), S. Basaran (Turkey) |
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J.P. Fryns |
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| Behavioural phenotypes in chromosomal syndromes/rearrangements. | ||
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A first step to unravel genes and pathways involved in neurocognitive functioning |
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L. Shaffer |
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| Mechanisms of terminal deletions | ||
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N. Tommerup |
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| Mendelian cytogenetics: challenges and potentials | ||
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selected abstracts: |
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S.Dyer |
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| Application of high resolution CGH in constitutional genetic analyses | ||
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M. Riegel |
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| An unusual reciprocal translocation detected by subtelomeric FISH: Interstitial and not terminal. | ||
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01:00 - 02:00 PM |
Genosystems Satellite Meeting - Europauditorium |
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| Clinical Application of MicroArray CGH Technology | ||
| Chaired by M. Benkhalifa (Paris, France) and O. Zuffardi (Pavia, Italy) | ||
| M. Benkhalifa (Paris, France) | ||
| Basic Technology of Spectral Genomics Micro Arrays | ||
| M. Mohammed (San Diego, CA, USA) | ||
| Overview of BAC Micro Arrays application for Genome Profiling in Oncology | ||
| E. Maher (Edimburgh, Scotland) | ||
| Potential Application of Micro Arrays in Constitutional Diagnostics | ||
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Afternoon |
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02:00 PM |
Poster session no. 1 |
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| 2. Cancer cytogenetics: hematological tumors | ||
| 3. Cancer cytogenetics: solid tumors | ||
| 6. Chromosomal structure and nuclear domains | ||
| 8. Genomic instability and mutagenesis | ||
| 11. Laboratory services and management | ||
| 13. Prenatal and preimplantation cytogenetics | ||
| 15. From chromosomes to microarrays | ||
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03:00 PM |
Concurrent sessions |
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Cancer cytogenetics: hematological tumors – Europauditorium |
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Chaired by O. Haas (Austria), K. Michalova (Czech Republic) |
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B.D.Young |
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| Expression profiling of acute myeloid leukaemia | ||
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I.Wlodarska |
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| Cytogenetics of lymphoma: an update | ||
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S.Strehl |
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| The network of fusion genes. | ||
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selected abstracts: |
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S. Röttgers |
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| Inversion inv(19)(p13q13) as the first chromosome causing a heterozygous targeted disruption of an oncogene | ||
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R.Harris |
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| Inferring something from seeing nothing a cautionary MLL FISH tale | ||
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L. van Zutven |
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Detection of new specific chromosome aberrations in acute leukemia using molecular cytogenetic techniques |
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Karyotype evolution – Sala Italia |
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Chaired by M. Rocchi (Italy), L. Iannuzzi (Italy) |
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| F. Yang | ||
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Reconstructing the ancestral karyotype of eutherian mammals: a systematic approach |
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S. Müller |
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| Reconstruction of landmark rearrangements during primate karyotype evolution | ||
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selected abstracts: |
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T.J. Robinson |
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| Correspondence of chromosome segments in low numbered (Equidae) and high numbered (Rhinocerotidae) Perissodactyla, and genetic confirmation of an F1 Black x White rhinoceros hybrid by FISH and microsatellite analysis | ||
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A. Ruiz-Herrera |
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| Molecular cytogenetic conservation of human aphidicolin-induced fragile sites in Papionini (Primates) species. | ||
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C. Sandig |
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| Molecular characterization of the pericentric inversion of chimpanzee chromosome 3 homologous to human chromosome 4 | ||
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G.P. di Meo |
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Comparative FISH-mapping of sixty loci in sheep (Ovis aries, 2n=54) and river buffalo (Bubalus bubalis, 2n=50) chromosomes |
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04:30 PM |
Coffee-break and Trade Exhibition |
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05:00 PM |
Concurrent sessions |
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Plant cytogenetics – Sala Italia |
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Chaired by C. Ceoloni (Italy), J.S. Heslop-Harrison (UK) |
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J.S. Heslop-Harrison |
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| Chromosomes, chromatin, centromeres and comparisons | ||
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M. Feldman |
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| The impact of polyploidy on genome evolution in wheat | ||
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selected abstracts: |
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H. Schneeweiss |
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| Genomes of polyploids and chromosomal evolution in Hepatica (Ranunculaceae) | ||
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S.-M. Rogalska |
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| The transposase of Ac/Ds system is located at rye telomere heterochromatin | ||
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Laboratory services and management – Europauditorium |
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Chaired by U. Kristoffersson (Sweden), F. Dagna Bricarelli (Italy) |
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O. Bartsch |
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| FISH European Quality Assessment - five year experience of the German, Austrian, and Swiss scheme | ||
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K. Simola |
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| EQA in classical cytogenetics - the Labquality experience | ||
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D. Taruscio |
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| EQA in classical cytogenetics - the Italian experience | ||
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F. Dagna-Bricarelli and Ulf Kristoffersson |
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Closing discussion. Where are we going? |
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| selected abstract: | ||
| A. Baroncini | ||
| The Emilia-Romagna genetics portal | ||
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06:00 PM |
General Assembly of the European Cytogeneticists Association – Europauditorium |
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Morning |
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09:00 AM |
Plenary session |
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Cancer cytogenetics: solid tumors – Europauditorium |
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Chaired by F. Mitelman (Sweden), G. Romeo (Italy) |
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F. Mitelman |
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| Recurrent cytogenetic changes in epithelial tumors | ||
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selected abstracts: |
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| P. Ambros | ||
| Differential gene expression in neuroblastoma cell lines | ||
| S. Imreh | ||
| The "elimination test" suggests a correlation between evolutionary and cancer related chromosome breakage | ||
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A. Dahlén |
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| Fusion, disruption and overexpression of HMGA2 in bone and soft-tissue chondromas | ||
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A.E. Alsop |
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| Distribution of breakpoints on chromosome 18 and 8p in breast, colorectal and pancreatic carcinomas | ||
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J. Decker |
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| Characterisation of a complex chromosome 3 rearrangement in a new case of hereditary renal cell carcinoma | ||
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M. Daniely |
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| Combined analysis of morphology and FISH for the monitoring of bladder cancer | ||
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11:00 AM |
Coffee-break and Trade Exhibition |
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11:30 AM |
Genomic instability and mutagenesis – Europauditorium |
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Chaired by J. Garcia-Sagredo (Spain), L. De Carli (Itlay) |
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M. Schwab |
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| Fragile sites in genomic instability - Molecular cloning strategy for fragile site DNA sequences. | ||
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L. Migliore |
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| Mutagenetic approaches in evaluating DNA integrity in human male germ cells | ||
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selected abstracts: |
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G.L. Buglia |
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| Analysis by Q-FISH of telomere length variation in human lymphocytes exposed to ionising radiation and microgravity. | ||
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I. Hayata |
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| Imperceptible effect of high-level natural radiation on health revealed by chromosome study in the Southern China. | ||
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U. Rovigatti |
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| MYCN gene amplification and tumorigenesis triggered in human neuroblasts by Micro-Foci inducing Virus (MFV). | ||
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A. de Leon |
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| Analysis of mutagenic effects of mobile phone radiofrequency by CBMN test. | ||
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01:00-02:30 |
Abbott Satellite Symposium - Sala Italia |
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Genetic Testing in Pre- and Postnatal Diagnostics: Clinical Practice and Future Trends |
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| Chair L. Gianaroli (Bologna, Italy) | ||
| R. Glaubitz (Hannover, Germany) | ||
| Rapid FISH Analysis - Experience of Over 10.000 Samples | ||
| D. Ledbetter (Atlanta, USA) | ||
| Towards a Molecular Karyotype with Array CGH | ||
| L. Gianaroli (Bologna, Italy) | ||
| Clinical Aspects of Preimplantation Genetic Diagnosis | ||
| C. Magli (Bologna, Italy) | ||
| Technical Aspects of Preimplantation Genetic Diagnosis | ||
| A. Plesch (Heidelberg, Germany) | ||
| Automated FISH Analysis: State of the Art | ||
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Afternoon |
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02:00 PM |
Poster session no. 2 |
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| 1. Animal cytogenetics | ||
| 4. Chromosomal basis of sterility and reproduction failure | ||
| 5. Chromosomal mosaicism | ||
| 7. Clinical cytogenetics | ||
| 9. Imprinting and epigenetics | ||
| 10. Karyotype evolution | ||
| 12. Plant cytogenetics | ||
| 14. Duplicons, Centromeres, telomeres and chromosome rearrangements | ||
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03:00 PM |
Concurrent sessions |
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Animal cytogenetics – Sala Italia |
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Chaired by P. Popescu (France), E. Olmo (Italy) |
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F. Fontana |
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| Recent advancements and perspectives in fish cytogenetics | ||
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E. Capanna |
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| Chromosomal evolution in mice thirty years after | ||
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J. Rubes |
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| Aneuploidy in farm animals | ||
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selected abstract: |
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F. Kasai |
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| Identification of the homologue of chicken Z chromosome in turtle and crocodile | ||
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Prenatal and preimplantation cytogenetics – Europauditorium |
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Chaired by V. Baranov (Russia), E. Blennow (Sweden) |
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J. Wolstenholme |
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| Mosaicism and prenatal diagnosis: what we know and what we need to know | ||
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Y. Verlinsky |
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| Origin of aneuploidy in oocytes and embryos | ||
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selected abstracts: |
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R. Hochstenbach |
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| Rapid aneuploidy detection in uncultured amniocytes by MLPA (Multiplex Ligation-dependent Probe Amplification) | ||
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M.C. Magli |
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| Chromosomal abnormalities in preimplantation embryos | ||
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P. N. Scriven |
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| The analytical performance of preimplantation genetic diagnosis (PGD) for reciprocal translocations | ||
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L. Voullaire |
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Complex chromosome abnormality in human cleavage embryos characterized by comparative genomic hybridization |
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04:30 PM |
Coffee-break and Trade Exhibition |
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05:00 PM |
Concurrent sessions |
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Chromosomal basis of sterility and reproduction failure - Europauditorium |
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Chaired by D. Rabineau (France), G. Palka (Italy) |
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L. Stuppia |
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| Identification on chromosome 8q11 of an autosomal precursor of the VCY2 gene, mapped within the AZFc locus of the Y chromosome and involved in male infertility | ||
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selected abstracts: |
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K. Kucheria |
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| Genotype and phenotype correlation in infertile men with Yq microdeletions | ||
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J.Parczewska |
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| An attempt to identify additional gene sequences at chromosomal position 13q31 in a patient with OAT- Syndrome. | ||
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Prochi Madon |
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| 45,X,t(Y;13)(q11.2;q11),-der(13) with Y microdeletions in an azoospermic male. | ||
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G. Ogur |
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Silencing of a structural trisomy 10 and deletion of FMR1 gene in a female with unbalanced X-autosome translocation 46,X,der(X)t(X;10)(q27;q24) |
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Chromosomal mosaicism – Sala Italia |
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Chaired by K. Miller (Germany), J.P. Bureau (France) |
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K. Madan |
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| Low-level mosaicism with X-aneuploidy in women with reproductive failure | ||
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J. Crolla |
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| FISH studies in 102 patients with aniridia reveals somatic mosaicism, complex chromosomal rearrangements as well as visible and cryptic interstitial 11p deletions | ||
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selected abstract: |
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| J.R. Vermeesch | ||
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Mosaicism del(8p)/inv dup(8p) in a dysmorphic female infant: A mosaic formed by a meiotic error at the 8p OR gene and an independent terminal deletion event |
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08:00 PM |
Conference dinner |
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Palazzo Isolani - Bologna |
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Via Santo Stefano, 16 |
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Morning |
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09:00 AM |
Plenary session |
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Chromosomal structure and nuclear domains – Europauditorium |
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Chaired by T. Cremer (Germany), C. Redi (Italy) |
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R. van Driel |
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| Nuclear organization and gene expression | ||
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S. Kozubek |
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| Detailed studies of the 3D structure of chromosome territories | ||
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selected abstracts: |
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L.A. Parada |
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| Cell-type specific spatial organization of genomes | ||
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10:00 AM |
Imprinting and epigenetics – Europauditorium |
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Chaired by A. Schinzel (Switzerland), B. Dallapiccola (Italy) |
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W. Reik |
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| Imprinting and epigenetic reprogramming in development and disease | ||
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A. Baumer |
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Molecular investigations of the methylation status of imprinted genes in Beckwith-Wiedemann syndrome patients |
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11:00 AM |
Coffee-break and Trade Exhibition |
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11:30 AM |
From chromosomes to microarrays – Europauditorium |
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Chaired by N. Carter (UK), P.F. Pignatti (Italy) |
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M. Speicher |
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| Seven fluorochrome M-FISH and Array CGH: powerful tools for the delineation of small structural rearrangements | ||
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N. Carter |
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| Chromosomes in disarray: Applications of DNA microarrays in the study of chromosomes and their aberrations | ||
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selected abstracts: |
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C. Melotte |
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| Genotype-phenotype corrleation by FISH and microarray in atypical Wolf-Hirschhorn patients | ||
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P. Patsalis |
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| Detection of submiscroscopic chromosomal abnormalities of unknown location using microarray based technology: The first whole chromosome X microarray and the beginning of the molecular karyotype | ||
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01:00 PM |
Closing session – Europauditorium |
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L. Larizza (Italy), A. Schinzel (Switzerland) |
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International Standing Committee on Human Cytogenetic Nomenclature |
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Meeting on September 9, 2-7 PM |
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